The cees dekker Diaries

The cees dekker Diaries

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‘The second is nanopores, which can be our oldest line of analysis and which has now resulted in DNA sequencers determined by nanopores. We pull specific DNA strands by way of a nanopore and may then go through off the nucleotide sequence. Extremely not too long ago, we even managed to study out a single protein for The 1st time applying This system. But this line of investigation is not merely about building resources, but in addition about genuine Organic issues.

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Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metallic clusters

This yielded a breakthrough. In only a few months, we ended up capable of evaluate transport by a person one-walled carbon nanotube. Depending on small-temperature experiments by an excellent PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with really long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.

Direct immobilization of indigenous yeast iso-1 cytochrome c on bare gold: fast electron relay to redox enzymes and zeptomole protein-movie voltammetry

Duration Charge of unique carbon nanotubes by nanostructuring While using the scanning tunneling microscope

2011, initial in vitro measurements of transport throughout one biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination

2003, demonstrated the very first biosensors made outside of a carbon nanotube; fixed the framework and mechanism of DNA repair proteins; and discovery of a new system for fabricating stable-condition nanopores for DNA translocation

At this time, we also understood that it ought to be possible to use only one semiconducting carbon nanotube to help make a transistor — and we established out to really make it. We stretched specific semiconducting nanotubes across metallic electrodes and utilized the underlying silicon substrate to be a gate electrode, creating The fundamental 3-terminal layout of the subject-result transistor (Fig.

An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes

Mother nature Physics thanks the anonymous reviewers for his or her contribution towards the peer review of the function.

2008, initial observation of protein-coated DNA translocation through nanopores; fixed the origin with the electrophoretic power on DNA in nanopores; found a significant velocity maximize of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in ceesdekker.net liquid

The biophysicist from Delft – who has been Among the most cited scientists during the Netherlands For a long time – takes his accountability to contribute to your explanation and popularisation of his get the job done on the border of physics and biology exceptionally significantly and consistently appears during the media; if not to look at his function, then about the connection between science and his Christian faith.